Animatus Biosciences
Our technology is licensed from University of Houston, with additional independent patents supporting platform technology.
Patents
Bioreactor for Stem Cell Expansion
Owned by Synthecon, Inc. and licensed to Animatus Biosciences. U.S. Patent No.: 10,214,715.Read More↗
Serum Response Factor Regenerates Senescent Cells
U.S. ApplicationNo.:/U.S. Patent No.: 62/614,190, filed/Issued: Filed, Inventors: Robert Schwartz, Dinaker Iyer, UHID: 2018-010.Read More↗
Enhanced Cardiomyocyte Regeneration
US Patent No.: 2021/0187123A1Read More↗
Publications
Brief report: SRF-dependent MiR-210 silences the sonic hedgehog signaling during cardiopoesis.
Zheng G, Tao Y, Yu W, Schwartz RJ. Stem Cells. 2013; 31:2279-85.Read More↗
Protein tyrosine phosphatase-like A regulates myoblast proliferation and differentiation through MyoG and the cell cycling signaling pathway.
Lin X, Yang X, Li Q, Ma Y, Cui S, He D, Lin X, Schwartz RJ, Chang J. Mol Cell Biol. 2012; 32:297-308.Read More↗
Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart.
Niu Z1, Iyer D, Conway SJ, Martin JF, Ivey K, Srivastava D, Nordheim A, Schwartz RJ. Proc Natl Acad Sci U S A. 2008;105:17824-9.Read More↗
SMYD1, the myogenic activator, is a direct target of serum response factor and myogenin.
Li D, Niu Z, Yu W, Qian Y, Wang Q, Li Q, Yi Z, Luo J, Wu X, Wang Y, Schwartz RJ, Liu M. Nucleic Acids Res. 2009; 37:7059-71.Read More↗
Identification of direct serum response factor gene targets during DMSO induced P19 cardiac cell differentiation.
Zhang, S.X., Gras, E,G., Wycuff, D.R., Marriot, S.J., Kadeer, N., Yu, W., Olson, E.N., Garry, D.J., Parmacek, M.S. and Schwartz, RJ. 2005; J. Biol. Chem. 280, 19115 – 19126Read More↗
PKG-1α mediates the transcriptional activity of GATA4.
Yanlin, Ma, Y Wang, J, Yanhong, Y, Schwartz, RJ. 2016; Cellular Signaling 8:585-594.Read More↗
Conversion of human cardiac progenitor cells into cardiac pacemaker-like cells.
Raghunathan S, Islas JF, Mistretta B, Iyer D, ShiL, Gunaratne PH, Ko G, Schwartz RJ, McConnel BK. J Mol Cell Cardiol 2019; 138: -12-32Read More↗
Beta-Adrenergic stimuli and rotating suspension culture enhance conversion of human adipogenic mesenchymal stem cells into highly conductive cardiac progenitors.
Islas JF, Abbasgjolizadeh R, Dasco C, Potaman VN, Navran S, Bond RA, Iyer D, Birla R, Schwartz. J Tissue Eng Regen Med. 2020;
14:306-318.Read More↗
A Highly Conductive 3D Cardiac Patch Fabricated Using Cardiac Myocytes Reprogrammed from Human Adipogenic Mesenchymal Stem Cells.
Abbasgolizadh R, Islas JF, Navran S, Potaman VN, Schwartz RJ, Birla RK. Cardiovas Eng Technol 2020; 11: 205-218.Read More↗
Mutant SRF and YAP synthetic modified mRNAs drive nuclear replication.
Xiao S, Liang R, Muili AB, Cao X, Navran, S, Schwartz RJ, Iyer D. J Cardiovasc Aging 2022;2:29
STEMIN and YAP 5SA synthetic modified mRNAs regenerate and repair infarcted mouse hearts.
Xiao S, Liang R, Lucero E, McConnell BK, Chen Z, Chang J, Navran S, Schwartz RJ, Iyer D. J Cardiovasc Aging 2022;2:31.
